IQ-1S (free acid)
IQ-1S (free acid)
CAS: 23146-22-7
Molecular Formula: C15H9N3O
IQ-1S (free acid) - Names and Identifiers
| Name | IQ-1S (free acid) |
| Synonyms | IQ1S IQ-1S IQ 1S IQ-1S CS-2230 IQ-1 sodium IQ-1S (free acid) 11H-Indeno[1,2-b]quinoxalin-11-one oxime Sodium |
| CAS | 23146-22-7 |
IQ-1S (free acid) - Physico-chemical Properties
| Molecular Formula | C15H9N3O |
| Molar Mass | 247.25 |
| Solubility | DMSO: ≥ 32 mg/mL |
| Appearance | powder |
| Color | white to beige |
| Storage Condition | Sealed in dry,2-8°C |
| In vitro study | Compound IQ-1S is a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1α, IL-1β, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages. The effect of IQ-1S is evaluated on LPS-induced cytokine production in human PBMCs. Among the 12 cytokines analyzed, LPS (200 ng/mL) consistently induces five (IL-1α, IL-1β, IL-6, IL-10, and TNF-α) in PBMCs compared with DMSO-treated control cells. Production of all of these cytokines is significantly inhibited by 20 μM IQ-1S. Among them, TNF-α production is inhibited completely by IQ-1 (>99%), the levels of IL-1α, IL-1β, and IL-10 are decreased by 85%, and IL-6 production is decreased by 33%. |
| In vivo study | When mice are dosed with 12.5 and 30 mg/kg IQ-1S (The sodium salt of IQ-1S) i.p., the serum exposure of the compound is also good, with AUC 0-12h values of 2.9 and 7.4 μM/h, respectively. |
IQ-1S (free acid) - Risk and Safety
| WGK Germany | 3 |
IQ-1S (free acid) - Preparation solution concentration reference
| 1mg | 5mg | 10mg | |
|---|---|---|---|
| 1 mM | 4.044 ml | 20.222 ml | 40.445 ml |
| 5 mM | 0.809 ml | 4.044 ml | 8.089 ml |
| 10 mM | 0.404 ml | 2.022 ml | 4.044 ml |
| 5 mM | 0.081 ml | 0.404 ml | 0.809 ml |
Last Update：2024-01-02 23:10:35
IQ-1S (free acid) - Reference Information
| biological activity | IQ-1S are JNK3 inhibitors, and Kd values for JNK3, JNK2 and JNK1 are 87 nM, 360 nM and 390 nM respectively. |
| target | TargetValue jnk3 (cell-free assay) 87 nm jnk2 (cell-free assay) 360 nm jnk1 (cell-free assay) 390 nm |
| Target | Value |
| JNK3 (Cell-free assay) | 87 nM |
| JNK2 (Cell-free assay) | 360 nM |
| JNK1 (Cell-free assay) | 390 nM |
| in vitro study | Compound IQ-1S is a potent, noncytotoxic inhibitor of pro-inflammatory cytokine [interleukin (IL)-1 α, IL-1β, IL-6, IL-10, tumor necrosis factor (TNF)-α, interferon-γ, and granulocyte-macrophage colony-stimulating factor] and nitric oxide production by human and murine monocyte/macrophages. The effect of IQ-1S is evaluated on LPS-induced cytokine production in human PBMCs. Among the 12 cytokines analyzed, LPS (200 ng/mL) consistently induces five (IL-1α, IL-1β, IL-6, IL-10, and TNF-α) in PBMCs compared with DMSO-treated control cells. Production of all of these cytokines is significantly inhibited by 20 μ M IQ-1S. Among them, TNF-α production is inhibited completely by IQ-1 (>99%), the levels of IL-1α, IL-1β, and IL-10 are decreased by 85%, and IL-6 production is decreased by 33%. |
| in vivo study | when mice are dosed with 12.5 and 30 mg/kg IQ-1S (the sodium salt of IQ-1S) I. p., the serum exposure of the compound is also good, with AUC 0-12h values of 2.9 and 7.4 μ m/h, respectively. |
Last Update：2024-04-10 22:29:15
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Spot supply
Product Name: IQ-1S (free acid) Visit Supplier Webpage Request for quotationCAS: 23146-22-7
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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